Sandfly maxadilan exacerbates infection with Leishmania major and vaccinating against it protects against L. major infection.

Antigenic diversity in maxadilan, a salivary protein from the sand fly vector of American visceral leishmaniasis.

The salivary protein maxadilan (MAX) is a vasodilator and immunomodulator from the sand fly vector of the protozoan parasite Leishmania chagasi. Vaccinating BALB/c mice with sand fly salivary gland extracts or with MAX protects the host against L. major infection. Because of the potential use of MAX in an anti-Leishmania vaccine, we characterized the vertebrate host IgG response to MAX in the p...

Sandfly Maxadilan Exacerbates Infection

Bivalent DNA Vaccination with Genes Encoding Leishmania major Cysteine Proteinases Type I and II Protects Mice Against Infectious Challenge

MONTHLY VARIATION O F LEISHMANIA MAJOR MON-26 INFECTION RATES IN PHLEBOTOMUS PAPATASI (DIPTRA : PSYCHODIDAE) FROM RODENT BURROWS IN BADROOD AREA OF IRAN

Following an epidemiological survey of zoonotic cutaneous leishmaniosis (ZCL) in some villages of Badrood, a rural district north of the city of Natanz, central Iran, Phlebotomus (Phlebotomus ) papatasi Scopoli were found to be naturally infected with Leishmania (Leishmania) major zymodeme MON-26. Sandflies were collected and dissected biweekly from rodent burrows during sandfly season, Ap...

Immunization against Leishmania major infection in BALB/c mice using a subunit-based DNA vaccine derived from TSA, LmSTI1, KMP11, and LACK predominant antigens

Objective(s): To design a multivalent DNA vaccine encoding the most immunogenic regions of the Leishmania major antigens including TSA (Thiol-specific antioxidant protein), LmSTI1 (Leishmania major stress-inducible protein1), LACK (Leishmania homologue of receptors for activated C Kinase), and KMP11 (kinetoplastid membrane protein-11) on BALB/c mice.M...